| Food & Diet

Hesperidin, The Chemical That Might Make Make You Save The Peel?

By Tyler Woodward

Hesperidin is a chemical compound that is found in citrus fruits like oranges and tangerines. Hesperidin is primarily found in the peels of citrus fruits, but is also in smaller quantities in the fruit themselves. Hesperidin is a type of flavonoid with some potent health effects when its absorbed into the body.

In order to be absorbed into the bloodstream it’s believed that hesperiden must be converted into its another form, hesperetin, which is found in much smaller quantities naturally in citrus fruits. Although some hypothesize that bacteria in our large intestine may be able to convert hesperidin into hesperetin, allowing for it to be absorbed into the bloodstream. 


Benefits Of Hesperidin:

Benefits Of Hesperidin

  • May Help Reduce Inflammation
  • May Help Decrease “Bad” Cholesterol Levels 
  • May Lower Estrogen Levels 
  • May Improve Skin Health 

Read More: Movement is Medicine | A Guide To Moving Better

How Hesperidin Works:

How Hesperidin Works

Hesperidin is believed to exert a number of biological effects in the body in a variety of ways:

First, hesperidin has a similar effect to other flavonoids like apigenin and chrysin which has been shown to be an aromatase inhibitor. Aromatase is the enzyme that converts testosterone into estrogen in the body and by inhibiting this enzyme you prevent testosterone from being converted into estrogen. This may help to increase testosterone levels by stopping the “loss” of testosterone into estrogen, allowing testosterone to remain longer in the body.

Hesperidin also activates the enzyme acetylcholinesterase. Acetylcholinesterase breaks down acetylcholine from the postsynaptic neuro in the brain. Acetylcholine is an excitatory neurotransmitter that is involved in many biological processes including learning and memory, but too much of any of the excitatory neurotransmitters can cause overexcitation of the neurons which can prevent the neurons from functioning properly and even toxicity. 

Additionally hesperidin acts as a potent antioxidant in the body. Antioxidants are compounds that bind to free radicals in the body helping to prevent the accumulation of oxidative stress or “inflammation” as result of too many free radicals in the body.  Hesperidin specifically was found to lower the release of inflammatory nitric oxide intermediates from lipopolysaccharides as a result of “bad” bacteria leaking through the gut wall. These qualities are believed to result in the many anti-inflammatory benefits of hesperidin.

Last, but not least, hesperidin has been shown to be able to positively modulate the levels of lipids like serum triglycerides and cholesterol levels in the blood. Too high levels of fatty molecules like triglycerides, free fatty acids, and cholesterol are believed to be a contributing factor developing cardiovascular disease. Hesperidin in this effect may have some medicinal-like effects by improving blood flow and insulin sensitivity.

Read More: 10 Potent Benefits Of Naringenin

How To Supplement With Hesperidin: 

How To Supplement With Hesperidin

Oral supplementation of hesperidin seems to be pretty readily absorbed through the intestines and has a relatively high degree of bioavailability. When purchasing a hesperidin supplement it's important to make sure that it is pure and does not contain large amounts of impurities. A great option to get hesperidin in your diet without supplementation is through eating the peel of citrus fruits. Marmalade is a tasty, delicious, and super-healthy snack.


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